21c Museum Hotel St. Louis

21c Museum Hotel St. Louis, St. Louis, MO — photo 3

About 21c Museum Hotel St. Louis

In downtown St. Louis, 21c Museum Hotel occupies a 1926, 10-story Renaissance Revival YMCA building and combines a contemporary art museum with hotel accommodations and more than 14,000 square feet of exhibition and event space. The hotel hosts weddings, receptions and rehearsals, with Idol Wolf catering. Its Locust Street Amphitheater is an outdoor option for wedding ceremonies and welcome receptions, with in-ground power for lighting and sound. Guest room blocks are available for wedding parties.

The facts

Guests: Up to 325 guests
Setting: Indoor & outdoor
Kind of place: Hotel · Museum
Last updated: November 2026

This listing was compiled by wedplan.ai from the venue’s own website and public listings. Work here? Claim the page to keep it current.

On the big wedding guides

Listed on WeddingWire (checked November 2026)
Not listed on Zola (checked November 2026)

How to reach 21c Museum Hotel St. Louis

Website: 21cmuseumhotels.com/stlouis
Phone: (314) 940-2333
Address: 1528 Locust Street

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